October 25, 2014

Ranitidine Classification, Indications, Mechanism of Action and Side-effects

Ranitidine Classification

Ranitidine is an oral prescribe medication that belongs to the drug classification called H2 or histamine 2 blockers. Histamine, scientifically speaking, is a chemical that is naturally occurs in the person’s stomach and functions as a stimulator of the stomach’s cells or otherwise known as parietal cells to be able to produce acid.

Ranitidine Indications

Ranitidine works by blocking the acid production in the person’s stomach. Since it belongs to the drug classification called H2 blockers which is indicated to reduce the histamine action on the parietal cells found in the stomach.  The following are the indications for the usage of Ranitidine:

Stomach Ulcer Problem

The ranitidine is often prescribed to persons that are suffering from ulcer problems or those persons who have acid induced inflammation in their stomach.

GERD or Gastroesophageal Reflux Disease problem

Aside from that, ranitidine is also indicated for the treatment of GERD or Gastroesophageal Reflux Disease. Gastroesophageal Reflux Disease is a medical condition wherein there is back flow of the acid from the stomach to the person’s esophagus which leads to the injury of the esophagus and heartburn.

Zollinger Ellison syndrome

Lastly, ranitidine is also indicated to persons who suffer from Zollinger Ellison syndrome which is a medical term that is given when a person’s stomach is able to produce excessive acid.

Other indication for the use of ranitidine includes:

  • Acid indigestion
  • Sour stomach
  • Preventing stress ulcers or stress ulcer prophylaxis
  • Stomach damage due to over usage of NSAIDs or nonsteroidal anti inflammatory drugs
  • Aspiration of the stomach when the person undergoes anesthesia
  • Treating upper portion of the gastrointestinal bleeding
  • Erosive esophagitis
  • Protect from duodenal and peptic ulcers

Ranitidine Mechanism of Action

As mentioned earlier, the ranitidine is a Histamine 2 antagonist which works to inhibit the histamine at the parietal cell located in the stomach. What it does is it suppresses the secretion of the acid of the parietal cells and the stimulation of the acid secretion after the consumption of food. It does not at all affect the pentagastrin stimulated factor secretion or otherwise known as serum gastrin and pepsin secretion.

What it does is that the ranitidine will bind at the H2 receptor sites on the parietal cells in the stomach. Once this happens, there will be a reduction of the nocturnal and basal gastric acid secretion. Another action of ranitidine is that it will increase the bacterial flora in the gastric aspect such bacteria like nitrate reducing kind of organism.

Ranitidine Side Effects

The side effects that are associated when one uses ranitidine are as follows:

  • Diarrhea
  • Fatigue
  • Insomnia
  • Pain in the muscles
  • Anemia
  • Depression
  • Easy bleeding
  • Losing of hair
  • Rash
  • Nausea
  • Constipation
  • Headache
  • Stomach pain
  • Vomiting
  • Jaundice of the eyes or skin
  • Changes in the visual aspect

Aside from the ones mentioned above, ranitidine may also lead to other serious side effects. When a person notices unusual things after taking ranitidine, he or she should call and consult his or her physician as soon as possible to be able to adjust or perhaps change the medication or the like depending on the assessment of the physician.

Guest Author Bio

Dr. Amarendra currently writes for Accessrx, an online facilitator for discrete medications such as Viagra, Cialis and Levitra online.  Dr. Amarendra has extensive background in health and wellness and enjoys offering tips on the AccessRx Research Center and AccessRx Health Blog.

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